How could I spoil this movie anyway? If you didn't know what it was from the trailers, then you must have spent the last 20 years in a basement.
I won't waste your time trying to describe the plot -- just look at the movie title to get the gist -- but I'll give you my quick thoughts...
1) If you happen to indulge (and I haven't in years), see this movie as stoned as possible. It will be much, much funnier.
2) If you liked Neil Patrick Harris in the incredibly underrated Undercover Brother, his appearance in this movie is the Anti-Lance, and made it worth the $6.50 matinee price I paid. (Note also that Smart Brother from UB is also in this movie, so that's another reason to go if you're a UB fan.)
3) The movie actually has a lot of fun with many stereotypes (not just the requisite Asian Guy and Indian Guy), so even though I was completely sober and watching it at 11:30 in the morning in an otherwise empty theater, I had fun. And hey, at under 90 minutes, it kept me entertained, with fast pace, a minimum of gross-out humor, lots of sex and drug references (with none of the former actually present but lots of the latter), and some great dialogue.